The highest governing body in Isabela State University is the Board of Regents. Its members are drawn from both the University and the private and public sectors. The current Board of Regents is composed of: 

	HON. MARITA R. CANAPI CHAIRPERSON Commissioner,Commission on Higher Education
	RICMAR P. AQUINO, Ph.D. VICE CHAIRPERSON University President, Isabela State University
	HON. JOEL VILLANUEVA Chair, Committee on Higher and Technical Education  Represented by: HON. BERNARD F. DY City Mayor, Cauayan City, Isabela
	HON.  MARK O. GO Chairperson, Committee on Higher and Technical Education Represented by: HON. FAUSTINO A. DY V Congressman 6th Legislative District of Isabela
	HON. NARCISO A. EDILLO Regional Executive Director, Department of Agriculture, R02
	HON. VIRGINIA G. BILGERA Regional Director, Department of Science and Technology, R02
	HON. DIONISIO C. LEDRES, JR. OIC Regional Director, National Economic and Development
	HON. RUBEN V. LOPEZ Private Sector Representative
	HON. JANIS RAE S. ESCAÑO Private Sector Representative
	HON. DROLLY P. CLARAVALL President, ISU Faculty Federation
	HON. PAUL VINCENT R. MAURICIO President, ISU Alumni Federation
	HON. MARK D. ASUNCION President, Supreme Student Council Federation